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pentobarbital will lessen the level or effect of lefamulin by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Prevent or Use Alternate Drug. Prevent coadministration of lefamulin with solid or reasonable CYP3A inducers Unless of course the profit outweighs risks. Watch for minimized efficacy.pentobarbital decreases levels of elvitegravir/cob